17-hydroxy-6-methylenepregn-4-ene-3,20-dione 17-acetate

17-hydroxy-6-methylenepregn-4-ene-3,20-dione 17-acetate - Names and Identifiers

Name	17-hydroxy-6-methylenepregn-4-ene-3,20-dione 17-acetate
Synonyms	Nsc 58799 Dehydromedroxyprogesterone acetate 17-Acetoxy-6-methylene-4-pregnene-3,20-dione 6-Methylene-17-acetoxypregna-4-ene-3,20-dione 17-Acetyloxy-6-methyleneprogn-4-ene-3,20-dione 17-(Acetyloxy)-6-methylenepregn-4-ene-3,20-dione 17-hydroxy-6-methylenepregn-4-ene-3,20-dione 17-acetate
CAS	32634-95-0
EINECS	251-133-8

17-hydroxy-6-methylenepregn-4-ene-3,20-dione 17-acetate - Physico-chemical Properties

Molecular Formula	C24H32O4
Molar Mass	384.50848
Density	1.14±0.1 g/cm3(Predicted)
Melting Point	248-251℃ (methanol )
Boling Point	507.6±50.0 °C(Predicted)
Storage Condition	Room Temprature
Physical and Chemical Properties	Chemical properties crystallization. Melting point> 220 ℃.
Use	Use an intermediate of megestrol.

17-hydroxy-6-methylenepregn-4-ene-3,20-dione 17-acetate - Risk and Safety

HS Code

2915399500

17-hydroxy-6-methylenepregn-4-ene-3,20-dione 17-acetate - Upstream Downstream Industry

Raw Materials

oxyma
Formaldehyde diisopropyl acetal
3,17-DIHYDROXY-PREGNA-3,5-DIEN-20-ONE DIACETATE
17-(Acetyloxy)-3-Methoxy-pregna-3,5-dien-20-one
Formaldehyde
Ethyl dichlorophosphate
DIETHOXYMETHANE
Dimethoxymethane

17-hydroxy-6-methylenepregn-4-ene-3,20-dione 17-acetate - Production method

16, 17α-epoxypregnan-4-ene-3, 20-dione (I. e. epoxyprogesterone) can be used by (epoxy group and hydrogen bromide) addition, catalytic hydrogenation (except 16-position Bromine), (3-ketone, 17 α-hydroxy) acetylation (simultaneous formation of 3-position and 5-position double bonds), hydrolysis (removal of 3-position acetyl group, 3-ketone, 4-diene recovery), to generate 17 α-acetoxy progesterone (ie 17 α-hydroxypregnost-4-ene-3, 20-dike-17-acetate), then (3-position with triethyl orthoformate) etherification, (6-position with dimethylformamide) formylation and reduction to obtain 3-ethoxy-17α-hydroxy-6-hydroxymethylpregnant-3-, 5-diene-20-keto-17-acetate, and finally hydrolysis (3-position keto, 4-position double bond recovery, and form 6-position methylene) to obtain the product.

Last Update：2024-04-10 22:29:15